Dosage ; Dosing: Adult
Bronchoconstriction (asthma, COPD):
Oral: Up to 15 mg/kg 4 times/day, individualize dosage
Dosing: Geriatric
Refer to adult dosing.
Dosing: Renal Impairment
Combinations ; - see below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Silbephylline | Minerva | Salama Pharmaceuticals Ltd. | 200mg | 25 | Tablet | per tablet | KES 225 |
| Silbephylline | Minerva | Salama Pharmaceuticals Ltd. | 500mg | 6 | Injection | per ml | KES 84 |
| Silbephylline | Minerva | Salama Pharmaceuticals Ltd. | 400mg | 6 | Suppositories | KES 120 |
| Dyphylline (Diprophylline) More info | |
|---|---|
| Mode Of Action | Phosphodiasterase inhibitors such as theophylline and aminophylline relax smooth muscles of bronchi, and pulmonary blood vessels resulting in increase in intracellular cAMP and subsequent smooth muscle relaxation. |
| Drug Indication | Reversible airways obstruction and severe acute asthma |
| Precautions | Cardiac/hepatic/peptic diseases, hypoxia, hypertension, alcoholism hyperthyroidism, epilepsy, pregnancy and lactation, elderly dehydration. |
| Contra-Indications | Hypersensitivity reactions to any xanthine, peptic ulcers, and epilepsy |
| Side Effects | GI disturbances, tachycardia-palpitation, CNS effects, metallic taste, sweat, tremor, diuresis, seizures, brain damage, alopecia, proteinuria. |
| Special Information | 7-(2,3-dihydroxypropyl) theophylline. |
| Pregnancy Category | Category A1: |
| Pregnancy Category Description | Drugs which have been taken by a sizeable number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. |
| Drug Category | DRUGS ACTING ON RESPIRATORY SYSTEM |
| Drug Sub-Category | Bronchial spasm relaxants |